Current Prognosis for Patients With C3G or Primary IC-MPGN




Question 1 of 4

C3G and primary IC-MPGN are 2 rare glomerular diseases. Approximately how many people across the US are affected by C3G and primary IC-MPGN?

C3G=complement 3 glomerulopathy; IC-MPGN=immune complex membranoproliferative glomerulonephritis.













Staining Patterns Related to C3G

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Question 2 of 4

Which staining pattern is characteristic of C3G under immunofluorescence microscopy?

C3=complement component 3; C3c=complement component 3c; C3G=complement 3 glomerulopathy; eGFR=estimated glomerular filtration rate; IC-MPGN=immune complex membranoproliferative glomerulonephritis; Ig=immunoglobulin; IgA=immunoglobulin A.













Current C3G and Primary IC-MPGN Treatment Options and Limitations

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Question 3 of 4

True or False: Complement overactivation in C3G and primary IC-MPGN leads to excessive deposition of C3 breakdown fragments (and Ig in primary IC-MPGN) in the glomeruli, resulting in damage and a decline in kidney function.

C3=complement component 3; C3G=complement 3 glomerulopathy; IC-MPGN=immune complex membranoproliferative glomerulonephritis; Ig=immunoglobulin.





Question 4 of 4

Most treatment approaches cannot effectively address the complement overactivation underlying both diseases. As a result, what percentage of children and adults with C3G or primary IC-MPGN, respectively, progress to kidney failure within 10 years of diagnosis?

C3G=complement 3 glomerulopathy; IC-MPGN=immune complex membranoproliferative glomerulonephritis.













 

100%




THANK YOU FOR TAKING THE CLINICAL CHALLENGE!

YOU ANSWERED 0 OUT OF 4 QUESTIONS CORRECTLY.



Question 1 of 4

C3G and primary IC-MPGN are 2 rare glomerular diseases. Approximately how many people across the US are affected by C3G and primary IC-MPGN?

Your response:






Question 2 of 4

Which staining pattern is characteristic of C3G under immunofluorescence microscopy?

Your response:













 

100%




THANK YOU FOR TAKING THE CLINICAL CHALLENGE!

YOU ANSWERED 0 OUT OF 4 QUESTIONS CORRECTLY.



Question 3 of 4

True or False: Complement overactivation in C3G and primary IC-MPGN leads to excessive deposition of C3 breakdown fragments (and Ig in primary IC-MPGN) in the glomeruli, resulting in damage and a decline in kidney function.

Your response:

C3=complement component 3; C3G=complement 3 glomerulopathy; IC-MPGN=immune complex membranoproliferative glomerulonephritis; Ig=immunoglobulin.













Question 4 of 4

Most treatment approaches cannot effectively address the complement overactivation underlying both diseases. As a result, what percentage of children and adults with C3G or primary IC-MPGN, respectively, progress to kidney failure within 10 years of diagnosis?

Your response:






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